Gene name:
Tcf4 (Itf2;Sef2) ;
Protein name:
Transcription factor 4 (TCF-4) ;
Alternative:
R8f DNA-binding protein ;Immunoglobulin transcription factor 2 (ITF-2;RITF-2) ;SL3-3 enhancer factor 2 (SEF-2) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin. Interacts with HIVEP2. Interacts with NEUROD2.
Function:
Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Interacts with the CCAAT displacement protein (CDP2) to bind the tyrosine hydroxylase enhancer.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MTSRDLGSHD | NLSPPFANSR | IQSKTERGSY | SSYGRENVQG | CHQSLLGGDM |
100:
DMGNPGTLSP | TKPGSQYYPY | SSNNARRRPL | HSSTMEVQTK | KVRKVPPGLP |
150:
SSVYAPSAST | ADYNRDSPGY | SSSKPAASTF | SSSFFMQDGH | HSSDPWSSSS |
200:
GMNQPGYGGM | LGNSHIPQSS | SYCSLHPHER | LSYPSHSSAD | INSSLPPMST |
250:
FHRSGTNHYS | TSSCTPPANG | TDSIMANRGT | GAAGSSQTGD | ALGKALASIY |
300:
SPDHTNNSFS | SNPSTPVGSP | PSLSAGTAVW | SRNGGQASSS | PNYEGPLHSL |
350:
QSRIEDRLER | LDDAIHVLRN | HAVGPSTAVP | GGHGDMHGII | GPSHNGAMGS |
400:
LGSGYGTGLL | SANRHSLMVG | AHREDGVALR | GSHSLLPNQV | PVPQLPVQSA |
450:
TSPDLNPPQD | PYRGMPPGLQ | GQSVSSGSSE | IKSDDEGDEN | LQDTKSSEDK |
500:
KLDDDKKDIK | SITRSRSSNN | DDEDLTPEQK | AEREKERRMA | NNARERLRVR |
550:
DINEAFKELG | RMVQLHLKSD | KPQTKLLILH | QAVAVILSLE | QQVRERNLNP |
589:
KAACLKRREE | EKVSSEPPPL | SLAGPHPGMG | DTANHMGQM
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Dog
Mouse
Rat
Polyclonal Antibody for Rat TCF-4
Polyclonal Antibody for Rat TCF-4
Polyclonal Antibody for Rat TCF-4
Polyclonal Antibody for Rat TCF-4
Polyclonal Antibody for Rat TCF-4
Monoclonal Antibody for Rat TCF-4
Monoclonal Antibody for Rat TCF-4
Monoclonal Antibody for Rat TCF-4
Monoclonal Antibody for Rat TCF-4
Monoclonal Antibody for Rat TCF-4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue :
Forebrain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 162-589 (ISOFORMS 1 AND 2)
strain :
New England Deaconess Hospital .
tissue :
Adrenal medulla .